Obesity Impact Draws Increased Scrutiny in GI Malignancies

Jason Harris
Published: Tuesday, Nov 06, 2018
Hisham Hussan, MD

Hisham Hussan, MD
Obesity is associated with an increased risk of early-onset colorectal cancer (CRC) among women and correlates with higher rates of cancer resections in gastrointestinal (GI) malignancies across age groups, according to recent research findings.

Body Mass Characterized

To date, investigators have not been able to identify the factors contributing to the increase in early-onset disease. Led by epidemiologists at Washington University School of Medicine in St. Louis, Missouri, investigators sought to examine the association between obesity, weight gain, and CRC. They analyzed data from the Nurses’ Health Study II, an ongoing study of female nurses (N = 85,256) in the United States who were free of cancer and inflammatory bowel disease when they enrolled in the study in 1989. The findings showed that the risk for developing CRC before age 50 years is nearly double for women who were obese, defined as a BMI ≥30.0, compared with those with a BMI of 18.5 to 22.9.
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