Gilteritinib Helps Set New Pace in Acute Myeloid Leukemia

Brittany Lovely
Published: Wednesday, Jun 26, 2019
Alexander E Perl, MD

Alexander E Perl, MD
Gilteritinib (Xospata) has the potential to reshape the treatment paradigm for patients with FLT3-positive acute myeloid leukemia (AML), according to Alexander E. Perl, MD, a leading investigator into the drug.

The FDA approved gilteritinib, a small molecule that inhibits FLT3 and other kinases, as single-agent therapy for patients with relapsed/refractory AML harboring a FLT3 mutation based on remission rates in the phase III ADMIRAL trial (NCT02421939).

In an interview with OncologyLive®, Perl, associate professor in the Division of Hematology/Oncology at the Perelman School of Medicine and a member of the Abramson Cancer Center, both at the University of Pennsylvania in Philadelphia, discussed gilteritinib’s place in the AML landscape and its potential future in the frontline setting.

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