Success Breeds a Need for Oncology Trials That Tackle Real-World Questions

Maurie Markman, MD
Published: Monday, Dec 30, 2019
Maurie Markman, MD, editor in chief, is president of Medicine and Science at Cancer Treatment Centers of America and clinical professor of medicine, Drexel University College of Medicine, Seattle Cancer Care Alliance

Maurie Markman, MD

The importance of randomized trials in oncology in the development of solid evidence-based care is well recognized. Data from such studies presented at major oncology meetings and published in high-impact medical journals can be practice changing. Randomized trials may reveal superior efficacy, such as improved progression-free or overall survival, or the study end point may involve noninferior outcomes with reduced clinically relevant toxicities. Of course, it is always hoped that practice-changing trial data will reveal improvement both in efficacy and in treatment-associated adverse effects.
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