Effects of UV Radiation Are Cumulative
An article in Oncogene further explains how ultraviolet (UV) radiation helps transform skin cells into basal cell carcinoma.
An article in Oncogene further explains how ultraviolet (UV) radiation helps transform skin cells into basal cell carcinoma. Cells exposed to UV radiation ramp up production of protein kinase D, an enzyme that helps cells survive. The effect is cumulative: more exposure causes more protein kinase D expression, increasing the likelihood that DNA damaged skin cells survive and replicate. Pretreating skin cells with antioxidants reduced protein kinase D activation, suggesting that free radicals also contribute to skin cancer development.
Articles in this issue
Medulloblastoma Subtypes Are Different Diseases
ASH 2010: CPX-351 Improves Response in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia
ASH 2010: Elotuzumab Highly Active in Patients With Advanced Myeloma
ASH 2010: Intensified R-ACVBP More Effective and More Toxic Than R-CHOP in Diffuse Large B-Cell Lymphoma
ASH 2010: Carfilzomib Shrinks Tumors in More Than One-Third of Pretreated Myeloma Patients
ASH 2010: Brentuximab Vedotin Produces High Response Rate in Relapsed or Refractory Hodgkin Lymphoma
ASH 2010: Bosutinib Shows Promise as First-line Treatment of Chronic Myelogenous Leukemia
ASH 2010: Multiple Benefits Observed for Bortezomib in Newly Diagnosed Myeloma Patients
FDA Green-Lights Phase III Trial for Drug-Eluting Microspheres in Liver Cancer
FDA Requests Label Change for Generic Docetaxel
FDA Considers Approval of Fusilev for Colorectal Cancer
Advisory Panel Discusses Expanded Indication for Avodart
FDA Approves Zactima
Effects of UV Radiation Are Cumulative
People in Britain Say Find Aliens, Cure Cancer
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