Targeting Cancer's Achilles Heel: DNA Damage Response Networks Beyond PARP

Jane De Lartigue, PhD
Published: Wednesday, Dec 26, 2018
In 2015, 3 scientists were awarded the Nobel Prize in Chemistry for their work detailing the molecular mechanisms that cells use to repair damaged DNA.1 Numerous repair pathways are activated in response to different types of damage, regulated and coordinated by the broader DNA damage response (DDR) network.

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Figure. Major DNA Repair Pathways and Potential Therapeutic Targets2-4

Major DNA Repair Pathways and Potential Therapeutic Targets

Maintaining Genomic Integrity

Cells are constantly under attack from a wide variety of potentially DNA-damaging assailants both within the organism and in the surrounding environment. DNA can be damaged by, among other things, exposure to ultraviolet light, ionizing radiation, toxic chemicals, reactive oxygen species, mechanical stress, and replication errors.
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Clinical Practice Connections™: From Diagnosis to Emerging Immunotherapeutic Options: Understanding the Burden and Risks in Peanut AllergySep 28, 20191.0
Enduring CME activity from the School of Breast Oncology®: 2018 Mid-Year Video UpdateSep 28, 20192.0
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