Looking for Zebras in Metastatic Colorectal Cancer

Christina T. Loguidice
Published: Friday, Jan 04, 2019
John L. Marshall, MD

John L. Marshall, MD

When you hear hoofbeats, think of horses not zebras.” The idea behind this medical adage is that horses are more common than zebras, so if you hear hoofbeats, they are much more likely to come from a horse than a zebra. However, colorectal cancer (CRC) requires more careful analysis. Although it’s one of the most commonly diagnosed cancers in the United States,1 and researchers’ understanding of the biology and pathophysiology of CRC has grown, its many variations require that each case be diagnosed with care.

, a panel of CRC experts discussed the heterogeneity of metastatic CRC (mCRC) and the need to identify patient subsets within this disease to enable a precision medicine approach. They also shared their insights on some immunotherapies that are in development.

Importance of Next-Generation Sequencing

Next-generation sequencing (NGS) has revolutionized cancer care, enabling researchers to better understand the complicated molecular mechanisms of oncogenesis and identify treatment targets to improve patient care and outcomes. Yet not all patients with mCRC are receiving NGS.
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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 2nd Annual International Congress on Oncology Pathology™Aug 31, 20191.5
Community Practice Connections™: 2nd Annual School of Nursing Oncology™Sep 28, 20191.5
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