The OncLive Breast Cancer condition center page is a comprehensive resource for clinical news and expert insights on various types of breast cancer, including those that are triple negative, hormone receptor positive, and/or HER2 positive. This page features news articles, interviews in written and video format, and podcasts that focus on treatment advances and ongoing research in breast cancer.
Biomarker Testing in Gastrointestinal and Lung Cancers
Comprehensive insights on biomarker testing practices for patients with lung or gastrointestinal cancers.
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Molecular Testing in Breast Cancer
A breast medical oncologist and nurse practitioner review molecular testing practices for patients with breast cancer.
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SABR to Oligoprogressive Lesions Delays Systemic Therapy Change in ER+ Advanced Breast Cancer
October 5th 2023Administration of stereotactic ablative body radiotherapy to oligoprogressive lesions delayed a change in systemic therapy in patients with estrogen receptor–positive/HER2-negative breast cancer enrolled to the prospective phase 2 AVATAR trial.
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Patients with breast cancer who received hypofractionated postmastectomy radiotherapy experienced similar toxicities vs those who received conventionally fractionated postmastectomy radiotherapy, according to a presentation shared at the 2023 American Society for Radiation Oncology Annual Meeting.
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Mechanisms of Action of Antibody-Drug Conjugates
The expert panel discusses the history of antibody-drug conjugates and explores their mechanisms of action.
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Overview of Antibody-Drug Conjugates (ADCs)
A panel of cancer-treating specialists introduce the discussion with a broad overview of antibody-drug conjugates (ADCs).
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FDA Grants Fast Track Designation to IDE161 for Select Pretreated BRCA1/2-Mutated HR+ Breast Cancer
September 27th 2023The FDA has granted fast track designation to IDE161 for use in adult patients with advanced or metastatic hormone receptor–positive, HER2-negative breast cancer harboring BRCA1/2 mutations who have progressed after at least 1 hormonal therapy, a CDK4/6 inhibitor, and a PARP inhibitor.
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Novel Sequencing Strategies May Expand Localized and Metastatic Breast Cancer Treatment Landscapes
September 27th 2023Jairam Krishnamurthy, MD, FACP, highlights the benefits of neoadjuvant therapy in early-stage HER2-positive breast cancer, treatment considerations for patients with HER2-negative disease who have progressed on an initial CDK4/6 inhibitor, and ongoing research that may address unmet needs in the field.
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Safety and Efficacy of Sacituzumab Govitecan in the Treatment of HR+/HER2- mBC
September 26th 2023Virginia Kaklamani, MD, and Elizabeth Diaz, PA-C, Diaz review the available safety and efficacy data from the TROPiCS-02 trial on the use of antibody drug conjugate sacituzumab govitecan for the treatment of HR+/HER2- metastatic breast cancer.
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Zotatifin Triplet May Improve Outcomes Post–CDK4/6 Inhibition in ER+ Breast Cancer
September 24th 2023Ezra Rosen, MD, PhD, highlights the early-phase investigation of zotatifin in estrogen receptor-positive metastatic breast cancer, explains the agent’s unique mechanism of action as well as its efficacy and safety in a heavily pretreated population, and underscores the need for improved sequencing of the myriad of treatment options in the post–CDK4/6 inhibitor space.
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European Commission Approves Elacestrant for Pretreated, ESR1+, ER+/HER2– Breast Cancer
September 20th 2023The European Commission has approved elacestrant for the treatment of postmenopausal women and men with estrogen receptor–positive, HER2-negative, locally advanced, or metastatic breast cancer with an activating ESR1 mutation who have disease progression following at least 1 line of endocrine therapy including a CDK4/6 inhibitor.
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Dr Graff on the Impact of Endocrine Therapy Interruption on Conception in Breast Cancer Survivors
September 19th 2023Stephanie L. Graff, MD, discusses the advantages of interrupting endocrine therapy in premenopausal patients with endocrine-responsive breast cancer who are seeking to conceive, based on findings from the phase 3 POSITIVE trial.
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Optimizing Treatment Strategies in the Evolving HR+/HER2- Breast Cancer Paradigm
September 19th 2023Over the past 10 years, data from studies including the TAILORx and RxPONDER studies have reshaped treatment standards for patients with hormone receptor–positive, HER2-negative breast cancer.
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