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Opinion|Videos|February 17, 2025

Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL

Author(s)David Miklos, MD, Haifaa Abdulhaq, MD, Frederick Locke, MD

An overview of third-line treatment options for DLBCL, including choices for patients who did not receive CAR T-cell therapy or transplant in second-line, strategies for those who progress after CAR T-cell or transplant, and the impact of bispecific antibodies and ADCs, with insights from key studies on Glofit and Epcor in relapsed/refractory DLBCL and their implications for patient selection and care.

Episodes in this series

EP. 1 Emerging Updates in Front-line Treatment Approach of DLBCL

EP. 1 Emerging Updates in Front-line Treatment Approach of DLBCL

EP. 2 Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

EP. 2 Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

EP. 3 The Evolving First-line Treatment Approach for DLBCL

EP. 3 The Evolving First-line Treatment Approach for DLBCL

EP. 4 Future Considerations for Front-line Treatment of DLBCL

EP. 4 Future Considerations for Front-line Treatment of DLBCL

EP. 5 Role of Testing in Treatment Decisions - ClonoSeq, PhaseSeq, MRD+Disease

EP. 5 Role of Testing in Treatment Decisions - ClonoSeq, PhaseSeq, MRD+Disease

$EP. 6 Second-line Treatment Landscape in Relapsed/Refractory DLBCL$

EP. 6 Second-line Treatment Landscape in Relapsed/Refractory DLBCL

$EP. 7 The Emerging Role of Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 7 The Emerging Role of Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 8 Safety Considerations for Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 8 Safety Considerations for Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 9 Real World Perspectives: Outcomes for CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 9 Real World Perspectives: Outcomes for CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 10 Real World Perspectives: Considerations and Challenges for CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 10 Real World Perspectives: Considerations and Challenges for CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 11 Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics$

EP. 11 Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics

$EP. 12 Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL$

EP. 12 Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL

$EP. 13 Bispecific Antibodies in the Relapsed/Refractory DLBCL Treatment Landscape$

EP. 13 Bispecific Antibodies in the Relapsed/Refractory DLBCL Treatment Landscape

$EP. 14 Future Perspectives for the Treatment of Relapsed/Refractory DLBCL$

EP. 14 Future Perspectives for the Treatment of Relapsed/Refractory DLBCL

Video content above is prompted by the following:

Please discuss current trials using bispecific antibody therapies in DLBCL.

Briefly discuss the available third-line (3L) options for treatment of DLBCL.

Dr Miklos: What would you choose for patients that did not receive CAR T-cell therapy or transplant in the 2L?
Dr Ghosh:What if patients progress after receiving CAR T-cell therapy or transplant in the 2L?
- Discuss the rationale for bispecific antibodies or antibody drug conjugates.

Dr Abdulhaq:Given the findings from bispecific antibodies in RR DLBCL, along with the FDA 3L approval of Glofit, how will 3L treatment choices change?

Elaborate on the key takeaways from Glofit in RR DLBCL (Dickinson et el. NEJM 2022) and Epcor in RR DLBCL (Thieblemont et al. JCO 2022).
ALL:How do these studies inform your care, and what patients are best suited for this type of regimen?
- When making treatment choices, what are the key differentiators between the two approved options that you consider?

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