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Opinion|Videos|February 10, 2025

Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics

Author(s)David Miklos, MD, Haifaa Abdulhaq, MD, Frederick Locke, MD

A discussion of current trials on bispecific antibody therapies in DLBCL, highlighting key takeaways from STARGLO on Glofit+GemOx in relapsed/refractory disease, the potential role of bispecifics in second-line treatment, and the patient populations and care settings most likely to benefit from these emerging options.

Episodes in this series

EP. 1 Emerging Updates in Front-line Treatment Approach of DLBCL

EP. 1 Emerging Updates in Front-line Treatment Approach of DLBCL

EP. 2 Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

EP. 2 Insights from POLARIX: How do Novel Perspectives Influence Treatment Outcomes in DLBCL?

EP. 3 The Evolving First-line Treatment Approach for DLBCL

EP. 3 The Evolving First-line Treatment Approach for DLBCL

EP. 4 Future Considerations for Front-line Treatment of DLBCL

EP. 4 Future Considerations for Front-line Treatment of DLBCL

EP. 5 Role of Testing in Treatment Decisions - ClonoSeq, PhaseSeq, MRD+Disease

EP. 5 Role of Testing in Treatment Decisions - ClonoSeq, PhaseSeq, MRD+Disease

$EP. 6 Second-line Treatment Landscape in Relapsed/Refractory DLBCL$

EP. 6 Second-line Treatment Landscape in Relapsed/Refractory DLBCL

$EP. 7 The Emerging Role of Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 7 The Emerging Role of Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 8 Safety Considerations for Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 8 Safety Considerations for Second-line CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 9 Real World Perspectives: Outcomes for CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 9 Real World Perspectives: Outcomes for CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 10 Real World Perspectives: Considerations and Challenges for CAR T-cell Therapy in Relapsed/Refractory DLBCL$

EP. 10 Real World Perspectives: Considerations and Challenges for CAR T-cell Therapy in Relapsed/Refractory DLBCL

$EP. 11 Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics$

EP. 11 Additional Perspectives Beyond CAR T-cell Regimens in Relapsed/Refractory DLBCL.: Bispecifics

$EP. 12 Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL$

EP. 12 Academic Insights for the Treatment of Later Relapsed/Refractory DLBCL

$EP. 13 Bispecific Antibodies in the Relapsed/Refractory DLBCL Treatment Landscape$

EP. 13 Bispecific Antibodies in the Relapsed/Refractory DLBCL Treatment Landscape

$EP. 14 Future Perspectives for the Treatment of Relapsed/Refractory DLBCL$

EP. 14 Future Perspectives for the Treatment of Relapsed/Refractory DLBCL

Video content above is prompted by the following:

Please discuss current trials using bispecific antibody therapies in DLBCL.

What are key takeaways from Glofit + GemOx in RR DLBCL (STARGLO: Gregory et al. ASH 2024). How do you foresee these results impacting future treatment choices?
- What other emerging bispecific antibody therapy 2L trials are you excited about?
Do you see a space for bispecific antibody therapy in 2L? If so, what patients do you think would most benefit from this potentially new option?
- Please comment on patient population and sites of care that would most benefit from bispecific antibodies in 2L.

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