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Opinion|Videos|December 24, 2024

CAR T-cell Therapy for B-ALL

A panelist discusses how CAR-T cell therapy patient selection involves evaluating disease characteristics like relapse/refractory status and tumor burden, patient-specific factors including performance status and organ function, with extramedullary disease requiring careful monitoring while isolated CNS disease may warrant alternative treatments or clinical trials.

Episodes in this series

EP. 1 CAR T-cell Therapy for B-ALL

EP. 1 CAR T-cell Therapy for B-ALL

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

Video content above is prompted by the following:

Please provide a general overview of the CAR-T cell therapy program at your center.What disease and/or patient-specific considerations guide the selection of CAR-T?How does the presence of extramedullary disease or isolated CNS disease impact your decision?

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