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Opinion|Videos|March 21, 2025

Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

Author(s)Bijal Shah, MD, MS, Katherine (Katie) Tobon, PharmD, Brenna Williams, FNP-C, APRN-NPI

Experts discuss the routine initiation of bridging therapy between leukapheresis and chimeric antigen receptor (CAR) T-cell infusion at their center; the pharmacist’s role in implementing this procedure; collaboration with the team on agent choice, dosage, and administration; and monitoring for disease control and adverse events as well as the observed impact of bridging therapy on outcomes post CAR T-cell therapy.

Episodes in this series

EP. 1 CAR T-cell Therapy for B-ALL

EP. 1 CAR T-cell Therapy for B-ALL

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

Video content above is prompted by the following:

At your center, is bridging therapy routinely initiated during the interval between leukapheresis and CAR T-cell infusion?

If so, as a pharmacist, what is your role in implementing this procedure?
With whom on the team do you communicate on choice of agent, dosage, administration frequency, and monitoring for disease control and adverse events?
What impact of bridging therapy have you observed on outcomes post CAR T-cell therapy?

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