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Opinion|Videos|March 14, 2025

Optimizing Molecular Profiling for B-ALL Treatment

Author(s)Bijal Shah, MD, MS, Katherine (Katie) Tobon, PharmD, Brenna Williams, FNP-C, APRN-NPI

Experts discuss the timing and process of obtaining molecular profiles for genetic variants and T-cell biomarkers during patient assessment, including the team member responsible for ordering the test and whether Moffitt Cancer Center uses a preferred assay for adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).

Episodes in this series

EP. 1 CAR T-cell Therapy for B-ALL

EP. 1 CAR T-cell Therapy for B-ALL

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

Video content above is prompted by the following:

In the course of patient assessment, when do you obtain a molecular profile for genetic variants and T-cell biomarkers?

Which team member obtains or orders the test?
Does Moffitt Cancer Center use a preferred assay for its adult patients with relapsed or refractory B-ALL?

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