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Opinion|Videos|March 28, 2025

Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

Author(s)Bijal Shah, MD, MS, Katherine (Katie) Tobon, PharmD, Brenna Williams, FNP-C, APRN-NPI

Experts discuss the steps taken to ensure optimal T-cell persistence with chimeric antigen receptor (CAR) T-cell therapy, exploring the underlying mechanisms of toxicity and T-cell exhaustion and the advantages of fast off-rate kinetics, defining durable remission post CAR T-cell therapy, and sharing their views on the benefits and risks of approved CAR T-cell therapies for adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).

Episodes in this series

EP. 1 CAR T-cell Therapy for B-ALL

EP. 1 CAR T-cell Therapy for B-ALL

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 2 Navigating Treatment Selections for B-ALL: Insights From the Moffitt Cancer Center

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 3 The Multidisciplinary Approach to CAR T-Cell Therapy for B-ALL

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 4 CAR T-Cell Therapy for B-ALL: Roles Within the Multidisciplinary Care Team

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 5 Optimizing Molecular Profiling for B-ALL Treatment

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 6 Multidisciplinary Clinical Perspectives: Factors That Influence CAR T-Cell Sequencing in B-ALL

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 7 Considerations Regarding Bridging Therapy for B-ALL CAR T-Cell Treatment

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 8 Obe-Cel for B-ALL: Insights Regarding Persistence, Toxicity, and Remission

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 9 CAR T-Cell Therapy Decisions in B-ALL: The Role of Obe-Cel in B-ALL Treatment

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 10 Managing Immunotoxicities With CAR T-Cell Therapy for B-ALL

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 11 Treatment Sequencing Decisions for B-ALL: Perspectives From Moffitt Cancer Center

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

EP. 12 Future Considerations for Treatment Sequencing in B-ALL

Video content above is prompted by the following:

What steps do you take to ensure the greatest T-cell persistence rate with CAR T-cell therapy?
With respect to toxicity and T-cell exhaustion, please explore the underlying mechanisms and advantages of fast off-rate kinetics.
In your opinion, what constitutes durable remission post CAR T- cell therapy?
Please share your views on the benefits and risks of approved and available CAR T-cell therapies for the adult patient population with relapsed or refractory B-ALL.

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