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Opinion|Videos|January 5, 2026

Choosing Between Targeted Therapies and Addressing Unmet Needs

Author(s)Stephen Liu, MD, Julia Rotow, MD, Alexander Spira, MD, PhD, FACP

Panelists discuss treatment selection, resistance challenges, and future directions in managing BRAF-mutated lung cancer.

Episodes in this series

5 panelists

EP. 1 ALK Alterations and Treatment Options for ALK+ NSCLC

5 panelists

EP. 2 Long-Term Data in ALK+ NSCLC

5 panelists

EP. 3 Spotlight on ROS1-Targeted Therapies in Advanced NSCLC

5 panelists

EP. 4 Treatment Options for ROS1+ Advanced NSCLC

5 panelists

EP. 5 Investigational Therapies and Ongoing Trials in ROS1+ NSCLC

5 panelists

EP. 6 Use of ROS1-Targeting Agents in Clinical Practice

5 panelists

EP. 7 Using Long-Term Data to Guide ALK+ NSCLC Treatment

5 panelists

EP. 8 Real-World Data in ALK+ NSCLC

5 panelists

EP. 9 Resistance Mechanisms and Molecular Testing in ALK Inhibitor–Treated NSCLC

5 panelists

EP. 10 Emerging Strategies for ALK+ NSCLC

5 panelists

EP. 11 Patient Profile and Treatment Selection in ALK+ NSCLC

5 panelists

EP. 12 Role of BRAF Mutations in NSCLC

5 panelists

EP. 13 Treatment Options for BRAF-Mutated Metastatic NSCLC

5 panelists

EP. 14 Combination Strategies in BRAF-Mutated NSCLC

5 panelists

EP. 15 Recent Clinical Data in BRAF-Mutated NSCLC

5 panelists

EP. 16 Choosing Between Targeted Therapies and Addressing Unmet Needs

Panelists address how clinicians differentiate between available targeted regimens based on clinical presentation, resistance profile, and patient preference. They emphasize that understanding the mechanisms behind primary and acquired resistance will inform future sequencing strategies.

The conversation extends to unmet needs, including limited data on subsequent-line therapy and the role of immunotherapy in resistant cases. Panelists highlight ongoing research into next-generation inhibitors and alternative approaches such as combination immunotherapy.

They conclude that continued innovation and biomarker-driven care are essential to overcoming current therapeutic limitations and improving long-term outcomes for patients with BRAF-mutated disease.

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