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Opinion|Videos|December 19, 2025

Treatment Options for BRAF-Mutated Metastatic NSCLC

Author(s)Stephen Liu, MD, Julia Rotow, MD, Alexander Spira, MD, PhD, FACP

Panelists discuss evolving treatment approaches for BRAF-mutated metastatic lung cancer and their clinical impact.

Episodes in this series

5 panelists

EP. 1 ALK Alterations and Treatment Options for ALK+ NSCLC

5 panelists

EP. 2 Long-Term Data in ALK+ NSCLC

5 panelists

EP. 3 Spotlight on ROS1-Targeted Therapies in Advanced NSCLC

5 panelists

EP. 4 Treatment Options for ROS1+ Advanced NSCLC

5 panelists

EP. 5 Investigational Therapies and Ongoing Trials in ROS1+ NSCLC

5 panelists

EP. 6 Use of ROS1-Targeting Agents in Clinical Practice

5 panelists

EP. 7 Using Long-Term Data to Guide ALK+ NSCLC Treatment

5 panelists

EP. 8 Real-World Data in ALK+ NSCLC

5 panelists

EP. 9 Resistance Mechanisms and Molecular Testing in ALK Inhibitor–Treated NSCLC

5 panelists

EP. 10 Emerging Strategies for ALK+ NSCLC

5 panelists

EP. 11 Patient Profile and Treatment Selection in ALK+ NSCLC

5 panelists

EP. 12 Role of BRAF Mutations in NSCLC

5 panelists

EP. 13 Treatment Options for BRAF-Mutated Metastatic NSCLC

5 panelists

EP. 14 Combination Strategies in BRAF-Mutated NSCLC

5 panelists

EP. 15 Recent Clinical Data in BRAF-Mutated NSCLC

5 panelists

EP. 16 Choosing Between Targeted Therapies and Addressing Unmet Needs

Panelists outline the current treatment paradigm for patients with BRAF-mutated metastatic disease, noting that targeted therapy combinations have become a mainstay for eligible individuals. They emphasize the importance of individualized care, as responses vary depending on disease burden and comorbidities.

The conversation covers how therapy sequencing, treatment duration, and management of adverse effects influence outcomes. Real-world data continue to validate the efficacy observed in clinical trials, confirming meaningful improvements in survival and symptom control.

In summary, panelists underscore that ongoing innovation and patient-tailored treatment remain critical to optimizing outcomes in this subset of lung cancer.

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