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Opinion|Videos|December 12, 2025

Patient Profile and Treatment Selection in ALK+ NSCLC

Author(s)Stephen Liu, MD, Julia Rotow, MD, Alexander Spira, MD, PhD, FACP

Panelists discuss individualized treatment selection based on age, comorbidities, and patient preferences in ALK-positive lung cancer.

Episodes in this series

5 panelists

EP. 1 ALK Alterations and Treatment Options for ALK+ NSCLC

5 panelists

EP. 2 Long-Term Data in ALK+ NSCLC

5 panelists

EP. 3 Spotlight on ROS1-Targeted Therapies in Advanced NSCLC

5 panelists

EP. 4 Treatment Options for ROS1+ Advanced NSCLC

5 panelists

EP. 5 Investigational Therapies and Ongoing Trials in ROS1+ NSCLC

5 panelists

EP. 6 Use of ROS1-Targeting Agents in Clinical Practice

5 panelists

EP. 7 Using Long-Term Data to Guide ALK+ NSCLC Treatment

5 panelists

EP. 8 Real-World Data in ALK+ NSCLC

5 panelists

EP. 9 Resistance Mechanisms and Molecular Testing in ALK Inhibitor–Treated NSCLC

5 panelists

EP. 10 Emerging Strategies for ALK+ NSCLC

5 panelists

EP. 11 Patient Profile and Treatment Selection in ALK+ NSCLC

5 panelists

EP. 12 Role of BRAF Mutations in NSCLC

5 panelists

EP. 13 Treatment Options for BRAF-Mutated Metastatic NSCLC

5 panelists

EP. 14 Combination Strategies in BRAF-Mutated NSCLC

5 panelists

EP. 15 Recent Clinical Data in BRAF-Mutated NSCLC

5 panelists

EP. 16 Choosing Between Targeted Therapies and Addressing Unmet Needs

Panelists explain that therapy decisions should consider patient characteristics such as performance status, comorbidities, and tolerance to potential side effects. Older adults and those with cardiac or metabolic risk factors may require dose adjustments or alternative regimens.

Shared decision-making is highlighted as an essential part of treatment planning. Discussing potential side effects and lifestyle implications helps patients engage actively in their care, improving adherence and satisfaction.

The segment concludes that tailoring treatment intensity and monitoring plans to each patient’s clinical profile ensures safer, more effective long-term management of ALK-positive disease.

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