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Opinion|Videos|November 8, 2024

Choosing Second-Line Therapies: Considering First Line Therapy Received

Author(s)Richard Finn, MD, Olatunji Alese, MD, Daneng Li, MD

Panelists discuss how to determine appropriate second-line and subsequent therapies for unresectable hepatocellular carcinoma after frontline treatment, emphasizing patient-specific factors and alternatives to clinical trial enrollment.

Episodes in this series

EP. 1 Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 1 Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 2 Treatment Decisions Based on BLCL Stage

EP. 2 Treatment Decisions Based on BLCL Stage

EP. 3 Current Treatment in First Line – IO + TKI or IO + IO

EP. 3 Current Treatment in First Line – IO + TKI or IO + IO

EP. 4 Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 4 Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 5 EMERALD-1 Study Results

EP. 5 EMERALD-1 Study Results

EP. 6 Discussion and Summary

EP. 6 Discussion and Summary

EP. 7 LEAP-012 Study Results

EP. 7 LEAP-012 Study Results

EP. 8 Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing

EP. 8 Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing

EP. 9 ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient

EP. 9 ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient

EP. 10 Choosing Second-Line Therapies: Considering First Line Therapy Received

EP. 10 Choosing Second-Line Therapies: Considering First Line Therapy Received

EP. 11 Discussion of CELESTIAL Trial and Second-Line Treatment in Japan

EP. 11 Discussion of CELESTIAL Trial and Second-Line Treatment in Japan

EP. 12 CELESTIAL Sub-Group Discussion

EP. 12 CELESTIAL Sub-Group Discussion

EP. 13 Discussion of RESORCE Trial

EP. 13 Discussion of RESORCE Trial

EP. 14 Real-World Treatment Data from the Phase 4 STELLAR Trial

EP. 14 Real-World Treatment Data from the Phase 4 STELLAR Trial

EP. 15 Importance of Real-World Data in Supporting Treatment Options

EP. 15 Importance of Real-World Data in Supporting Treatment Options

EP. 16 CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment

EP. 16 CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment

EP. 17 Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

EP. 17 Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

Video content above is prompted by the following:

Dr El-Khoueiry/Dr Kudo: After frontline therapy in unresectable hepatocellular carcinomauHCC, how do you determine the appropriate second- line and beyond therapy?
• What patient-specific factors do you consider?
• Other than clinical trial enrollment, what would you consider for second-line2L treatment?

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