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Opinion|Videos|November 29, 2024

Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

Author(s)Richard Finn, MD, Olatunji Alese, MD, Daneng Li, MD

Panelists discuss how ongoing trials and investigational agents, including the Checkmate 9DW study, could significantly influence future treatment approaches for unresectable hepatocellular carcinoma .

Episodes in this series

EP. 1 Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 1 Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 2 Treatment Decisions Based on BLCL Stage

EP. 2 Treatment Decisions Based on BLCL Stage

EP. 3 Current Treatment in First Line – IO + TKI or IO + IO

EP. 3 Current Treatment in First Line – IO + TKI or IO + IO

EP. 4 Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 4 Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 5 EMERALD-1 Study Results

EP. 5 EMERALD-1 Study Results

EP. 6 Discussion and Summary

EP. 6 Discussion and Summary

EP. 7 LEAP-012 Study Results

EP. 7 LEAP-012 Study Results

EP. 8 Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing

EP. 8 Discussion of LEAP-012 and EMERALD-1 Study Results and Appropriate Sequencing

EP. 9 ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient

EP. 9 ImBRAVE 050 Study Results and Discussion Around Who is a High-Risk Patient

EP. 10 Choosing Second-Line Therapies: Considering First Line Therapy Received

EP. 10 Choosing Second-Line Therapies: Considering First Line Therapy Received

EP. 11 Discussion of CELESTIAL Trial and Second-Line Treatment in Japan

EP. 11 Discussion of CELESTIAL Trial and Second-Line Treatment in Japan

EP. 12 CELESTIAL Sub-Group Discussion

EP. 12 CELESTIAL Sub-Group Discussion

EP. 13 Discussion of RESORCE Trial

EP. 13 Discussion of RESORCE Trial

EP. 14 Real-World Treatment Data from the Phase 4 STELLAR Trial

EP. 14 Real-World Treatment Data from the Phase 4 STELLAR Trial

EP. 15 Importance of Real-World Data in Supporting Treatment Options

EP. 15 Importance of Real-World Data in Supporting Treatment Options

EP. 16 CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment

EP. 16 CheckMate 9DW Study Results and Use of Ipiimumab/Nivolumab in First- and Second-Line Treatment

EP. 17 Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

EP. 17 Future Directions for Treating uHCC: Triplet Therapy, Epigenetic Therapy, Cytotoxic Agents, and Antibody-Drug Conjugates (ADCs

Video content above is prompted by the following:

Dr Finn to group (Iif time allows): Are there other trials or investigational agents that for which you are waiting for updates that could potentially impact affect how unresectable hepatocellular carcinoma uHCC is treated?

• Any additional thoughts on findings from Checkmate 9DW?

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