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Opinion|Videos|December 16, 2025

CHOPIN Trial: Percutaneous Hepatic Perfusion Plus Nivolumab/Ipilimumab in Metastatic Uveal Melanoma

Author(s)Prof. Andrea Forschner (DO), Dr. Shaheer Ahmad Khan (MD)

Prof. Andrea Forschner (DO), and Dr. Shaheer Ahmad Khan (MD), break down data from the phase 2 CHOPIN trial evaluating percutaneous hepatic perfusion plus nivolumab and ipilimumab in metastatic uveal melanoma.

Episodes in this series

2 experts are featured in this series.

EP. 1 Future Research Directions in Metastatic Uveal Melanoma

2 experts are featured in this series.

EP. 2 Current Treatment Standards in Metastatic Uveal Melanoma

2 experts are featured in this series.

EP. 3 Exploring Percutaneous Hepatic Perfusion in Metastatic Uveal Melanoma

2 experts are featured in this series.

EP. 4 CHOPIN Trial: Percutaneous Hepatic Perfusion Plus Nivolumab/Ipilimumab in Metastatic Uveal Melanoma

2 experts are featured in this series.

EP. 5 Exploring Potential Implications of CHOPIN Trial Data in Metastatic Uveal Melanoma

2 experts are featured in this series.

EP. 6 Other Strategies Incorporating Percutaneous Hepatic Perfusion in Metastatic Uveal Melanoma

2 experts are featured in this series.

EP. 7 Highlighting Other Uveal Melanoma Data From ESMO 2025 and Beyond

Prof.Andrea Forschner (DO), and Dr. Shaheer Ahmad Khan (MD), break down findings from the phase 2 CHOPIN trial (NCT04283890) investigating percutaneous hepatic perfusion combined with nivolumab (Opdivo) and ipilimumab (Yervoy) in patients with metastatic uveal melanoma. They review efficacy signals, response durability, and safety observations from this multimodal approach. Khan and Forschner also highlight how the trial provides insight into whether combining liver-directed therapy with checkpoint inhibition may enhance clinical benefit.

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