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Opinion|Videos|September 19, 2024

Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

Author(s)Shernan Holtan, MD, Haris Ali, MD, City of Hope

Medical experts discuss treatment selection for a specific clinical scenario.

Episodes in this series

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 3 Optimizing Chronic GVHD Therapy

EP. 3 Optimizing Chronic GVHD Therapy

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 6 Overview of the ROCKstar Study

EP. 6 Overview of the ROCKstar Study

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 13 Multidisciplinary Approaches to GVHD

EP. 13 Multidisciplinary Approaches to GVHD

Video content above is prompted by the following:

Dr Holtan: Please read this clinical scenario: Four months after having undergone allogenic hematopoietic stem transplant, a patient presents to the clinic with rashes over a large portion of his body and dry eyes. Based on clinical presentation and lab results, a diagnosis of moderate cGVHD is established. Patient was treated with steroids and subsequent calcineurin inhibitors for 4 to 6 weeks but showed little improvement in cGVHD symptoms.

Dr Ali:What other treatments could be used in such patients once steroid refractoriness is established?
- Are there factors you consider when choosing an alternate treatment option (efficacy, safety profile, clinical manifestations)?

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