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Opinion|Videos|August 29, 2024

Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

Author(s)Shernan Holtan, MD, Haris Ali, MD, City of Hope

Medical experts discuss navigating chronic GVHD.

Episodes in this series

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 3 Optimizing Chronic GVHD Therapy

EP. 3 Optimizing Chronic GVHD Therapy

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 6 Overview of the ROCKstar Study

EP. 6 Overview of the ROCKstar Study

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 13 Multidisciplinary Approaches to GVHD

EP. 13 Multidisciplinary Approaches to GVHD

Video content above is prompted by the following:

Dr Holtan: Please address the 3 phases of pathophysiology of cGVHD (early inflammation, chronic inflammation and dysregulated immunity, and aberrant repair and fibrosis) and the interplay between them.

How does inflammation affect different organs? And fibrosis?

Dr Ali:After confirmed diagnosis, please share your monitoring routine for patients with cGVHD.
- Are there certain symptom scores (eg, Lee skin symptom score) that are associated with better clinical outcomes?
- How do you share responsibility across subspecialty to monitor patients? Or other HCPS?

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