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Opinion|Videos|September 12, 2024

Overview of Advanced Therapies in cGVHD

Author(s)Shernan Holtan, MD, Haris Ali, MD, City of Hope

Medical experts discuss advanced therapies in cGVHD.

Episodes in this series

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 3 Optimizing Chronic GVHD Therapy

EP. 3 Optimizing Chronic GVHD Therapy

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 6 Overview of the ROCKstar Study

EP. 6 Overview of the ROCKstar Study

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 13 Multidisciplinary Approaches to GVHD

EP. 13 Multidisciplinary Approaches to GVHD

Video content above is prompted by the following:

Dr Holtan:Both ruxolitinib and ibrutinib are approved for use in cases of cGVHD that have failed 1 or more lines of systemic therapy.

Briefly summarize and critique clinical trial data with ruxolitinib (REACH3) and ibrutinib (Miklos D, et al. Blood. 2017) in patients with cGVHD.

Comment on adverse effects most frequently seen with ruxolitinib and ibrutinib and how you manage them.

In which patients would you hesitate to use ruxolitinib or ibrutinib (eg, patients at risk of developing thrombocytopenia, etc)?

Belumosudil is approved for treatment of cGVHD after failure of 2 or more systemic therapies. Can you elaborate on anti-inflammatory and antifibrotic properties of belumosudil and results from preclinical and human studies in reduction of fibrosis (Flynn R, et al. Blood. 2016)?
- How do these properties distinguish belumosudil from other targeted therapies for cGVHD?

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