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Opinion|Videos|September 26, 2024

AGAVE-201: Axatilimab for cGVHD

Author(s)Shernan Holtan, MD, Haris Ali, MD, City of Hope

Medical experts discuss the mechanism of action within axatilimab.

Episodes in this series

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 1 Differentiating Acute and Chronic Graft-vs-Host Disease

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 2 Navigating Chronic GVHD: Phases of Pathophysiology and Best Practices in Patient Monitoring

EP. 3 Optimizing Chronic GVHD Therapy

EP. 3 Optimizing Chronic GVHD Therapy

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 4 Navigating Treatment Decisions in Chronic GVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 5 Overview of Advanced Therapies in cGVHD

EP. 6 Overview of the ROCKstar Study

EP. 6 Overview of the ROCKstar Study

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 7 Considerations for Third-Line Treatment in Chronic GVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 8 Clinical Scenario: Treatment Selection in the third line and beyond in cGVHD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 9 Recent Updates: REACH3, ROCKstar, and RWD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 10 AGAVE-201: Axatilimab for cGVHD

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 11 Emerging Trends in Chronic GVHD: Promising Clinical Trials and the Future Treatment Landscape

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 12 Clinical Impact of Patient-Reported Outcomes in cGVHD

EP. 13 Multidisciplinary Approaches to GVHD

EP. 13 Multidisciplinary Approaches to GVHD

Video content above is prompted by the following:

Axatilimab is pending FDA approval for cGVHD after failure of at least 2 prior lines of systemic therapy. Discuss its mechanism of action (MOA) and how this MOA might add value to cGVHD treatment landscape.
Discuss phase 1/2 data (Kitko CL, et al. J Clin Oncol. 2022) and AGAVE-201 trial data with axatilimab for cGVHD (Wolff D, et al. ASH 2023).

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