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Opinion|Videos|January 30, 2025

Clinical Trials and Real-World Data on Brexu-Cel

Author(s)Kristen M. O’Dwyer, MD , Aaron Logan, MD, PhD, John Molina, MD, MEd

Panelists discuss how the dosing and lymphodepletion regimens of brexucabtagene autoleucel (brexu-cel), tisagenlecleucel (tisa-cel), and obecabtagene autoleucel (obe-cel) differ, with insights into obe-cel’s double infusion approach, as well as a deeper dive into the ZUMA-3 trial’s design and data updates with brexu-cel in relapsed/refractory acute lymphoblastic leukemia (R/R ALL).

Episodes in this series

EP. 1 Introduction to CAR T-Cell Therapies in R/R ALL

EP. 1 Introduction to CAR T-Cell Therapies in R/R ALL

EP. 2 Clinical Trials and Real-World Data on Brexu-Cel

EP. 2 Clinical Trials and Real-World Data on Brexu-Cel

EP. 3 Obe-Cel and MRD Outcomes: Insights and Comparisons

EP. 3 Obe-Cel and MRD Outcomes: Insights and Comparisons

EP. 4 Shifting Treatment Paradigms in R/R ALL

EP. 4 Shifting Treatment Paradigms in R/R ALL

EP. 5 Optimizing Bridging Therapies and Post–CAR T Approaches

EP. 5 Optimizing Bridging Therapies and Post–CAR T Approaches

EP. 6 Addressing Toxicities in CAR T-Cell Therapy

EP. 6 Addressing Toxicities in CAR T-Cell Therapy

EP. 7 Health Care Resource Utilization and Transition of Care

EP. 7 Health Care Resource Utilization and Transition of Care

EP. 8 Outpatient CAR T Therapy and Expanding Access

EP. 8 Outpatient CAR T Therapy and Expanding Access

EP. 9 Reflections and Future Directions in R/R ALL

EP. 9 Reflections and Future Directions in R/R ALL

Video content above is prompted by the following:

Aside from obe-cel’s different design, what are the differences between the dosing and lymphodepletion regimen among brexu-cel, tisa-cel, and obe-cel?
- Please comment on obe-cel’s double infusion approach.
Please review the ZUMA-3 trial study design and key data updates with brexu-cel.

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