Opinion|Videos|February 13, 2025
Addressing Toxicities in CAR T-Cell Therapy
Panelists discuss future directions and unmet needs for chimeric antigen receptor (CAR) T-cell therapy in relapsed/refractory (R/R) B-cell acute lymphocytic leukemia (ALL) as well as risk factors that may predict higher likelihoods of severe cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) in patients undergoing treatment.
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Video content above is prompted by the following:
- Dr. O’Dwyer to Dr. Molina: What are future directions or remaining unmet needs for CAR T-cell therapy in R/R B-cell ALL?
- Resource links: Roddie C et al. Risk factors associated with sub-optimal outcomes following obe-cel: what we have learned from the FELIX trial. ASH 2024 poster abstract or see Appendix 7
- Dr. O’Dwyer to Dr. Molina: As we know, CRS and ICANS are associated with CAR T-cell therapies, Dr Molina: Are there risk factors that can predict those who are at higher risk for developing severe CRS and/or ICANs?
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