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Opinion|Videos|February 13, 2025

Optimizing Bridging Therapies and Post–CAR T Approaches

Author(s)Kristen M. O’Dwyer, MD , Aaron Logan, MD, PhD, John Molina, MD, MEd

Panelists discuss the impact of blinatumomab’s FDA approval on sequencing chimeric antigen receptor (CAR) T-cell therapy for relapsed/refractory acute lymphoblastic leukemia (R/R ALL), the use of bridging therapies prior to CAR T infusion, and approaches to consolidation or maintenance treatment following CAR T therapy.

Episodes in this series

EP. 1 Introduction to CAR T-Cell Therapies in R/R ALL

EP. 1 Introduction to CAR T-Cell Therapies in R/R ALL

EP. 2 Clinical Trials and Real-World Data on Brexu-Cel

EP. 2 Clinical Trials and Real-World Data on Brexu-Cel

EP. 3 Obe-Cel and MRD Outcomes: Insights and Comparisons

EP. 3 Obe-Cel and MRD Outcomes: Insights and Comparisons

EP. 4 Shifting Treatment Paradigms in R/R ALL

EP. 4 Shifting Treatment Paradigms in R/R ALL

EP. 5 Optimizing Bridging Therapies and Post–CAR T Approaches

EP. 5 Optimizing Bridging Therapies and Post–CAR T Approaches

EP. 6 Addressing Toxicities in CAR T-Cell Therapy

EP. 6 Addressing Toxicities in CAR T-Cell Therapy

EP. 7 Health Care Resource Utilization and Transition of Care

EP. 7 Health Care Resource Utilization and Transition of Care

EP. 8 Outpatient CAR T Therapy and Expanding Access

EP. 8 Outpatient CAR T Therapy and Expanding Access

EP. 9 Reflections and Future Directions in R/R ALL

EP. 9 Reflections and Future Directions in R/R ALL

Video content above is prompted by the following:

Dr. O’Dwyer to Dr. Molina: With blinatumomab’s FDA approval in the earlier-line setting in ALL, does this impact how you sequence CAR-T cell therapy for your R/R ALL patients?
Dr. O’Dwyer to Dr. Shaughnessy: In real-life day-to-day practice, how often are you utilizing bridging therapy prior to CAR T cells, and what agents are you typically using? What is the role of bridging therapies prior to CAR T cells being infused?
Resource link: Park JH et al. Bridging therapies FELIX study. ASH 2024 poster abstract or see Appendix 6
Dr. O’Dwyer to Dr. Logan (then open to panelists): What is your consolidation or maintenance treatment approach post CAR T-cell therapy? Can CAR T-cell therapy be a stand-alone therapy?

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