Opinion|Videos|August 23, 2024
Clinical Trials to Increase Treatment Options in the Progressive Setting
Author(s)Jason Fangusaro, MD
The panel reviews ongoing clinical trials aimed at expanding treatment options for progressive pediatric low-grade gliomas (pLGG), with a specific focus on the PNOC021, PBTC-055, and NF111 studies, discussing their objectives, design features, and potential impact on future treatment strategies.
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Episodes in this series
- Please briefly describe the various treatment options that might be considered in R/R pLGG
- Clinical trial enrollment
- PNOC021: Phase I Trametinib + Everolimus in NF1 LGG/HGG (
NCT04485559 ) - NF111: Phase II Poly-ICLC in NF1 LGG (
NCT04544007 ) - PBTC-055: Phase I/II trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Trametinib and HCQ for BRAF fusion/duplication or NF1 (
NCT04201457 )
- PNOC021: Phase I Trametinib + Everolimus in NF1 LGG/HGG (
- Clinical trial enrollment
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