Opinion|Videos|August 2, 2024
Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors
Author(s)Jason Fangusaro, MD
The panel reviews ongoing clinical trials for non-BRAF V600E pediatric low-grade gliomas (pLGG), specifically highlighting the Phase III ACNS1831 and Phase III ACNS1833 studies, discussing their objectives, designs, and potential implications for future treatment strategies.
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Episodes in this series
- What are some ongoing Phase II/III trials in this space?
- Phase II Vinblastine +/- Bevacizumab in chemotherapy naïve pLGG (
NCT02840409 ) - Phase III ACNS1831: Selumetinib vs carboplatin/vincristine in NF1 pLGG (
NCT03871257 ) - Phase III ACNS1833: Selumetinib vs carboplatin/vincristine in non-V600E and non-NF1 pLGG (
NCT04166409 )
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