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Opinion|Videos|August 16, 2024

The Role of Tovorafenib in Treatment of Progressive pLGG

Author(s)Jason Fangusaro, MD

The panel reviews ongoing clinical trials aimed at expanding treatment options for progressive pediatric low-grade gliomas (pLGG), with a specific focus on the PNOC021, PBTC-055, and NF111 studies, discussing their objectives, design features, and potential impact on future treatment strategies.

Episodes in this series

3 KOLs are featured in this series.

EP. 1 Overview of pLGG presentation and categorization

3 KOLs are featured in this series.

EP. 2 Molecular Characterization of pLGG

3 KOLs are featured in this series.

EP. 3 Less Common Molecular Alterations in pLGG and Testing Recommendations

3 KOLs are featured in this series.

EP. 4 Standard of care for frontline treatment of non-V600E-specific pLGG tumors

3 KOLs are featured in this series.

EP. 5 Ongoing clinical trials for frontline treatment of non-V600E-specific pLGG tumors

3 KOLs are featured in this series.

EP. 6 Current Treatment of Patients with NF1 pLGG

3 KOLs are featured in this series.

EP. 7 Standard of Care Pptions Specific for Frontline Treatment of BRAF V600E-Mutated pLGG

3 KOLs are featured in this series.

EP. 8 Treatment Considerations for Progressive pLGG

3 KOLs are featured in this series.

EP. 9 Radiation and Targeted Therapies for Progressive pLGG

3 KOLs are featured in this series.

EP. 10 The Role of Tovorafenib in Treatment of Progressive pLGG

3 KOLs are featured in this series.

EP. 11 Clinical Trials to Increase Treatment Options in the Progressive Setting

3 KOLs are featured in this series.

EP. 12 Clinical scenario 1 - BRAFKIAA-1549 fusion

3 KOLs are featured in this series.

EP. 13 Alternatives and Considerations for Clinical Scenario 1

3 KOLs are featured in this series.

EP. 14 Clinical Scenario 2 - BRAFV600E

3 KOLs are featured in this series.

EP. 15 Potential Adverse Events With Targeted Therapies

3 KOLs are featured in this series.

EP. 16 Clinical Insights: Looking Forward for pLGG

Please briefly describe the various treatment options that might be considered in R/R pLGG
- Targeted therapies

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