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Opinion|Videos|February 27, 2025

CNS Activity in EGFR mNSCLC

Author(s)Heather A. Wakelee, MD, FASCO, Roy S. Herbst, MD, PhD

Panelists discuss how FLAURA2's impressive progression-free survival (PFS) benefit with osimertinib plus chemotherapy was particularly pronounced in patients with extrathoracic metastases, suggesting this combination approach may be especially valuable for this higher-risk population, though careful consideration of individual patient factors and toxicity management remains important in treatment selection.

Episodes in this series

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 3 CNS Activity in EGFR mNSCLC

EP. 3 CNS Activity in EGFR mNSCLC

EP. 4 Managing AEs With Osimertinib

EP. 4 Managing AEs With Osimertinib

EP. 5 MARIPOSA: Clinical Implications

EP. 5 MARIPOSA: Clinical Implications

EP. 6 EGFR mNSCLC: Future Directions

EP. 6 EGFR mNSCLC: Future Directions

Video content above is prompted by the following:

Please comment on FLAURA2 PFS benefits in patients with extrathoracic metastases. How do these findings influence treatment choices for this patient population?

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