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Opinion|Videos|February 20, 2025

FLAURA and FLAURA2: Key Efficacy and Safety Data

Author(s)Heather A. Wakelee, MD, FASCO, Roy S. Herbst, MD, PhD

Panelists discuss how osimertinib monotherapy demonstrated robust progression-free survival and overall survival benefits in FLAURA, while FLAURA2 showed that adding chemotherapy to osimertinib further improved progression-free survival (PFS) although overall survival (OS) data remains immature, leading to ongoing debate about the optimal first-line approach.

Episodes in this series

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 3 CNS Activity in EGFR mNSCLC

EP. 3 CNS Activity in EGFR mNSCLC

EP. 4 Managing AEs With Osimertinib

EP. 4 Managing AEs With Osimertinib

EP. 5 MARIPOSA: Clinical Implications

EP. 5 MARIPOSA: Clinical Implications

EP. 6 EGFR mNSCLC: Future Directions

EP. 6 EGFR mNSCLC: Future Directions

Video content above is prompted by the following:

Please comment on the PFS and OS data for osimertinib monotherapy vs combination therapies in FLAURA and FLAURA2.

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