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Opinion|Videos|March 13, 2025

MARIPOSA: Clinical Implications

Author(s)Heather A. Wakelee, MD, FASCO, Roy S. Herbst, MD, PhD

Panelists discuss how the MARIPOSA trial demonstrated strong efficacy with amivantamab plus lazertinib that appears comparable to FLAURA2’s results with osimertinib plus chemotherapy, although cross-trial comparisons should be interpreted cautiously given differences in study populations and the need for mature overall survival data from both trials.

Episodes in this series

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 3 CNS Activity in EGFR mNSCLC

EP. 3 CNS Activity in EGFR mNSCLC

EP. 4 Managing AEs With Osimertinib

EP. 4 Managing AEs With Osimertinib

EP. 5 MARIPOSA: Clinical Implications

EP. 5 MARIPOSA: Clinical Implications

EP. 6 EGFR mNSCLC: Future Directions

EP. 6 EGFR mNSCLC: Future Directions

Video content above is prompted by the following:

MARIPOSA evaluated amivantamab with lazertinib. How does the progression-free survival and overall response rate data from MARIPOSA compare with the outcomes seen in FLAURA2?

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