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Opinion|Videos|March 20, 2025

EGFR mNSCLC: Future Directions

Author(s)Heather A. Wakelee, MD, FASCO, Roy S. Herbst, MD, PhD

Panelists discuss how despite significant advances in EGFR-targeted therapy, critical unmet needs persist in EGFR-positive non–small cell lung cancer (NSCLC), including the need for better strategies to combat resistance mechanisms, more effective treatments for brain metastases, improved options for uncommon EGFR mutations, and the development of biomarker-driven approaches to optimize sequencing of available therapies.

Episodes in this series

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 1 EGFR mNSCLC: Treatment Overview and Challenges

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 2 FLAURA and FLAURA2: Key Efficacy and Safety Data

EP. 3 CNS Activity in EGFR mNSCLC

EP. 3 CNS Activity in EGFR mNSCLC

EP. 4 Managing AEs With Osimertinib

EP. 4 Managing AEs With Osimertinib

EP. 5 MARIPOSA: Clinical Implications

EP. 5 MARIPOSA: Clinical Implications

EP. 6 EGFR mNSCLC: Future Directions

EP. 6 EGFR mNSCLC: Future Directions

Video content above is prompted by the following:

What is your perspective on the unmet needs in EGFR-positive NSCLC, and how could future trials address these

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