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Opinion|Videos|January 16, 2026

COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

Author(s)Amer Zeidan, MBBS

Amer Zeidan, MBBS, unpacks data from a post hoc analysis of the COMMANDS trial of luspatercept in lower-risk MDS.

Episodes in this series

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

Amer Zeidan, MBBS, unpacks results from a post hoc analysis of the phase 3 COMMANDS trial assessing luspatercept (Reblozyl) in patients with lower-risk myelodysplastic syndromes (MDS) and early disease characteristics. He highlights outcomes across relevant subgroups and discusses implications for patient selection. Zeidan explains how these findings may further refine first-line treatment strategies.

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