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Opinion|Videos|January 9, 2026

Factors Influencing Treatment Initiation in Lower-Risk MDS

Author(s)Amer Zeidan, MBBS

Amer Zeidan, MBBS, discusses factors that can influence the initiation of treatment in lower-risk MDS.

Episodes in this series

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

Amer Zeidan, MBBS, outlines key clinical and disease-related factors that influence when to initiate treatment in lower-risk myelodysplastic syndromes (MDS). He discusses considerations such as transfusion burden, symptom severity, molecular features, and patient quality of life. Zeidan explains how individualized decision-making is essential to optimizing outcomes while avoiding overtreatment.

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