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Opinion|Videos|January 23, 2026

What to Watch in Higher-Risk MDS Research in 2026 and Beyond

Author(s)Amer Zeidan, MBBS

Amer Zeidan, MBBS, spotlights ongoing research to watch in higher-risk MDS after ASH 2025.

Episodes in this series

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

Amer Zeidan, MBBS, shifts focus to higher-risk myelodysplastic syndromes (MDS), highlighting key areas of ongoing and upcoming research to watch beyond the 2025 ASH Annual Meeting and Exposition. He discusses novel therapeutic strategies, combination approaches, and evolving endpoints of interest. Zeidan concludes by emphasizing how continued research may reshape outcomes for patients with higher-risk disease.

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