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Opinion|Videos|January 16, 2026

Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

Author(s)Amer Zeidan, MBBS

Amer Zeidan, MBBS, details data from ASH 2025 on real-world outcomes with luspatercept in lower-risk MDS.

Episodes in this series

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 1 Current Unmet Needs and Treatment Challenges in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 2 Factors Influencing Treatment Initiation in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 3 Real-World Outcomes for First-Line Luspatercept in Lower-Risk MDS

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 4 COMMANDS Post Hoc Analysis: Outcomes With First-Line Luspatercept in Lower-Risk MDS With Early Disease Characteristics

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 5 Other Notable Lower-Risk MDS Data From ASH 2025

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

EP. 6 What to Watch in Higher-Risk MDS Research in 2026 and Beyond

Amer Zeidan, MBBS, reviews real-world data presented at the 2025 ASH Annual Meeting and Exposition evaluating first-line luspatercept (Reblozyl) in patients with lower-risk myelodysplastic syndromes (MDS). He discusses effectiveness outcomes, transfusion independence rates, and how these findings compare with results from clinical trials. Zeidan places these data in context of routine clinical practice and evolving treatment algorithms.

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