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Othman Al-Sawaf, MD, discusses the efficacy of venetoclax plus obinutuzumab in patients with chronic lymphocytic leukemia, as demonstrated in the phase 3 CLL14 trial.
Othman Al-Sawaf, MD, a physician at the University Hospital of Cologne in Germany, discusses the efficacy of venetoclax (Venclexta) plus obinutuzumab (Gazyva) in patients with chronic lymphocytic leukemia (CLL), as demonstrated in the phase 3 CLL14 trial (NCT02242942).
Results from a long-term analysis of the study, which examined the combination vs chlorambucil and obinutuzumab in previously untreated patients with CLL, demonstrated that most patients who received venetoclax/obinutuzumab remain in remission, according to Al-Sawaf. Additionally, while many patients have not received additional treatment with either study regimen for more than 3 years, approximately 70% remain without disease progression, Al-Sawaf says. Moreover, only 35 disease progression events have been observed in the venetoclax/obinutuzumab arm, 17 of which have required an additional line of therapy, Al-Sawaf notes.
The majority of progression-free survival events in the venetoclax/obinutuzumab arm of the study were driven by deaths due to the patients' coexisting conditions or older age rather than CLL, Al-Sawaf adds. This suggests that the disease can be controlled with a fixed-duration treatment approach. These findings suggest that patients' quality of life is not dependent on their disease, but instead on coexisting conditions, Al-Sawaf says.
The ability to control the impact of disease on survival with a limited duration treatment approach in the frontline setting is a significant advancement in the field, Al-Sawaf concludes.