Video

Dr. Andtbacka Reviews the Efficacy of T-VEC in Melanoma

Robert Andtbacka, MD, from the Huntsman Cancer Institute, provides an overview of the phase III OPTiM trial that explored treatment with talimogene laherparepvecin patients with advanced melanoma.

Robert Andtbacka, MD, a surgeon and investigator with Intermountain Healthcare and Huntsman Cancer Institute, provides an overview of the phase III OPTiM trial that explored treatment with talimogene laherparepvec (T-VEC) in patients with advanced melanoma.

In the trial, 436 patients with unresected stage IIIB/C and IV melanoma were randomized 2:1 to intralesional T-VEC or subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). The primary endpoint of the trial was durable response rate (DRR), which was defined to include a continuous partial or complete response for greater than 6 months. Overall, patients treated with T-VEC experienced a DRR of 16% compared to 2% for GM-CSF.

The secondary endpoint of the trial was overall survival (OS), Andtbacka notes. At a planned interim analysis a trend toward an improvement in OS was observed in favor of T-VEC, with a hazard ratio of 0.79 (95% CI: 0.61, 1.02). This analysis was derived from 250 of the planned 290 events with a full analysis expected later this year.

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