Dr. Barata on Patient-Reported Toxicities With Axi-Cel at 1-Year of Follow-Up

Video

Anna Barata, PhD, discusses patient-reported toxicities with axicabtagene ciloleucel (axi-cel) in patients 1-year post-infusion.

Anna Barata, PhD, Department of Health Outcomes and Behavior, Moffitt Cancer Center, discusses patient-reported toxicities with axicabtagene ciloleucel (axi-cel; Yescarta) in patients 1-year post-infusion.

Findings from a survey-based study, which were presented in a virtual poster during the 2021 Transplantation and Cellular Therapy Meetings, showed that most patients who received axi-cel continued to experience some degree of toxicity 360 days post-infusion, says Barata. Notably, patients cited fatigue, insomnia, memory problems, and aching muscles/joints as common toxicities. More patients reported any memory problems at day 360 compared with prior to axi-cel, says Barata. However, symptoms such as decreased appetite, dry mouth, and constipation were reportedly improved by day 360 compared with baseline.

As such, long-term screening for symptoms is important to ensure patients receive early supportive care as needed, concludes Barata.

Related Videos
Corey Cutler, MD, MPH, and Hana Safah, MD, experts on GvHD
Guenther Koehne, MD, PhD
Lori A. Leslie, MD, an expert on lymphoma
Lori A. Leslie, MD, an expert on lymphoma
A panel of 4 experts on MDS
Patrick I. Borgen, MD
Kari Hacker, MD, PhD, NYU Grossman School of Medicine
Janos L. Tanyi, MD, PhD, associate professor, Obstetrics and Gynecology, Hospital of the University of Pennsylvania