Video

Dr. Berdeja Discusses Next Steps With bb2121 in Multiple Myeloma

Jesus Berdeja, MD, director of Multiple Myeloma Research, Sarah Cannon Research Institute, discusses next steps with the CAR T-cell therapy bb2121 in multiple myeloma.

Jesus Berdeja, MD, director of Multiple Myeloma Research, Sarah Cannon Research Institute, discusses next steps with the chimeric antigen receptor (CAR) T-cell therapy bb2121 in multiple myeloma.

The second-generation BCMA-targeted CAR T-cell therapy bb2121 was granted a breakthrough therapy designation by the FDA in November 2017, based on the preliminary clinical data from the phase I CRB-401 study.

In a study of patients with relapsed/refractory multiple myeloma presented at the 2017 ASH Annual Meeting, bb2121 induced complete remissions in 56% of patients. The treatment was generally well tolerated, with an objective response rate of 94%, and a partial response or better for 89% of patients. After 40-weeks of follow-up, median progression-free survival (PFS) has not yet been reached, but the 9-month PFS rate was 71%.

Berdeja says that an expansion phase of this trial is in the process of enrolling. There are already plans to move the cells earlier, and there will be a randomized trial in the third-line setting that is already being planned. There may be potential for bb2121 in the frontline setting for a subset of patients.

Related Videos
Chun Chao, PhD, MS
Mikkael A. Sekeres, MD
Noa Biran, MD
Ranee Mehra, MD, professor, medicine, medical oncology; director, Head and Neck Medical Oncology, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical System
Sumanta Kumar Pal, MD, FASCO, chair, Kidney and Bladder Cancer Disease Team; co-director, Kidney Cancer Program; professor, vice chair, Academic Affairs, Department of Medical Oncology & Therapeutics Research, City of Hope
Alfred L. Garfall, MD, MS
David Braun, MD, PhD
Anthony M. Hunter, MD
Amrita Krishnan, MD, City of Hope
Jonathan C. Trent, MD, PhD