Publication

Video

Supplements and Featured Publications
Novel Targets in the Ovarian Cancer Treatment Paradigm
Volume 1
Issue 1

Dr. Birrer on Remaining Questions in Platinum-Sensitive Ovarian Cancer

Michael J. Birrer, MD, PhD, discussed remaining questions when addressing platinum-sensitive ovarian cancer.

Michael J. Birrer, MD, PhD, vice chancellor, director, the Cancer Service Line, University of Arkansas for Medical Sciences (UAMS), director, Winthrop P. Rockefeller Cancer Institute, discussed remaining questions when addressing platinum-sensitive ovarian cancer.

Platinum-sensitive recurrence remains an important issue within ovarian cancer, and most patients with platinum-resistant disease will go through a phase of platinum sensitivity, Birrer says. Moreover, if patients have undergone maintenance therapy with PARP inhibitors, the question arises if they will remain sensitive to a PARP inhibitor after progression, Birrer adds.

The mechanism of resistance to a PARP inhibitor is likely heterogeneous, Birrer continues. Patients could develop resistance due to reversion mutations, fork stabilization, and P-glycoprotein activity, Birrer says. Ultimately, the mechanism of resistance will determine whether retreatment with a PARP inhibitor is an option, Birrer concludes.

Related Videos
Meletios (Thanos) Dimopoulos, MD, professor, therapeutics, Hematology Oncology, National and Kapodistrian University of Athens School of Medicine
Adam E. Singer, MD, PhD, Health Sciences Clinical Instructor, medicine, division lead, kidney cancer, Division of Hematology/Oncology, UCLA Health
Paul Chinfai Lee, MD, discusses the role of surgeons in regard to molecular testing in non–small cell lung cancer.
Neal D. Shore, MD, FACS
Sheldon M. Feldman, MD
Louis Crain Garrot, MD
Michel Delforge, MD, PhD
Thach-Giao Truong, MD
Aparna Parikh, MD
Benjamin P. Levy, MD, with Kristie Kahl and Andrew Svonavec