Dr. Blay on Treatment Considerations in Soft Tissue Sarcomas

Publication
Video
Supplements and Featured PublicationsDiagnosis and Trial Options in Sarcoma
Volume 1
Issue 1

Jean-Yves Blay, MD, discusses treatment considerations in patients with soft tissue sarcomas.

Jean-Yves Blay, MD, professor of Medicine, Université Claude Bernard, scientific director, Canceropole Lyon Rhône Alpes, vice chairman, EORTC Translational Research Advisory Committee, member, the Protocol Review Committee of EORTC, chairman, the Soft Tissue and Bone Sarcoma group of EORTC, the French Sarcoma Group, discusses treatment considerations in patients with soft tissue sarcomas.

Neoadjuvant plus adjuvant treatment is recommended for a small fraction of patients with specific characteristics in soft tissue sarcomas, Blay says. However, debates are ongoing about which patients could most benefit from neoadjuvant treatment, Blay adds. For example, patients with large grade 2 and 3 tumors may benefit from neoadjuvant therapy, which typically consists of doxorubicin plus ifosfamide (Ifex), Blay explains.

In the first-line setting for metastatic or relapsed disease, doxorubicin-based therapy is also recommended, Blay continues. Doxorubicin plus dacarbazine can be used for patients with leiomyosarcoma due increased response rates, progression-free survival rates, and overall survival, Blay explains. However, these benefits need to be tested in a randomized clinical trial, Blay concludes.

Related Videos
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,
Guenther Koehne, MD, PhD
Alessandro Villa, DDS, PhD, MPH
Joseph Mikhael, MD
Michael Richardson, MD
Minesh Mehta, MD
Ruben Olivares, MD
Phillip J. Koo, MD