Video

Dr. Liu on PARP Inhibitors in Recurrent Ovarian Cancer

Joyce F. Liu, MD, MPH, assistant professor of medicine, Harvard Medical School, and director of clinical research for gynecologic oncology at Dana-Farber Cancer Institute, discusses the use of PARP inhibitors in patients with recurrent ovarian cancer.

Joyce F. Liu, MD, MPH, assistant professor of medicine, Harvard Medical School, and director of clinical research for gynecologic oncology at Dana-Farber Cancer Institute, discusses the use of PARP inhibitors in patients with recurrent ovarian cancer.

All 3 PARP inhibitors—olaparib (Lynparza), niraparib (Zejula), and rucaparib (Rubraca)—are FDA-approved for use as maintenance therapy in patients with recurrent platinum-sensitive ovarian cancer. Although these agents show benefit across all women with ovarian cancer, their effect is most pronounced in women with BRCA-mutated disease, says Liu.

The only trial to show a benefit with a PARP inhibitor in the upfront maintenance setting is the phase III SOLO-1 trial, in which investigators examined olaparib in women with BRCA-mutated ovarian cancer. Notably, the study restricted treatment to 2 years in the absence of residual disease, says Liu; however, the benefit seems to extend well beyond that. Although the study showed a profound benefit in terms of progression-free survival with olaparib versus placebo, more mature data are needed to discern the agent’s impact on overall survival.

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