Sumanta K. Pal, MD, discusses the safety profile of cabozantinib in combination with atezolizumab in advanced renal cell carcinoma.
Sumanta K. Pal, MD, an associate clinical professor, Department of Medical Oncology and Therapeutics Research; co-director, Kidney Cancer Program; and a medical oncologist with City of Hope, discusses the safety profile of cabozantinib (Cabometyx) in combination with atezolizumab (Tecentriq) in advanced renal cell carcinoma (RCC).
Regarding safety, Pal says the toxicities that were reported with the combination were in line with those expected of cabozantinib plus atezolizumab.
Adverse effects with atezolizumab included a spectrum of non-overlapping immune-related toxicities, says Pal. Anticipated toxicities from cabozantinib included hand-foot syndrome, changes in liver function, and diarrhea.
Notably, the 40 mg and 60 mg doses of cabozantinib yielded similar rates of tolerability, Pal concludes.