Video

Dr. Pinilla-Ibarz on Choosing Second-line BTK Inhibitors in CLL

Javier Pinilla-Ibarz, MD, PhD, discusses the factors that go into choosing the optimal second-line BTK inhibitors for patients with chronic lymphocytic leukemia.

Javier Pinilla-Ibarz, MD, PhD, senior member, head of Lymphoma Section, Department of Malignant Hematology, Moffitt Cancer Center, discusses the factors that go into choosing the optimal second-line BTK inhibitors for patients with chronic lymphocytic leukemia (CLL).

Although second-generation BTK inhibitors generally elicit more durable responses, all BTK inhibitors, such as acalabrutinib (Calquence) and zanubrutinib (Brukinsa), have class effects, including bleeding and hypertension, Pinilla-Ibarz says. While the possibility for cardiovascular effects may make these second-generation BTK inhibitors seem suboptimal for certain high-risk patients, other drugs being investigated in CLL may still cause similar adverse effects (AEs) in longer follow-up, Pinilla-Ibarz notes.

Since AEs are a possibility with all BTK inhibitors, even well tolerated ones such as ibrutinib (Imbruvica), closely monitoring patients throughout treatment is important, Pinilla-Ibarz explains. Fortunately, patients with CLL have a variety of treatment options, and alternatives exist for those who respond poorly to certain agents, Pinilla-Ibarz concludes.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity