Benjamin Weinberg, MD, discusses the FDA approval of daraxonrasib, RASolute 302 survival data, safety considerations, and future RAS-targeted therapies in pancreatic cancer.
|Articles|March 9, 2011
- December 2010
- Volume 4
- Issue 12
Effects of UV Radiation Are Cumulative
Author(s)OBTN
An article in Oncogene further explains how ultraviolet (UV) radiation helps transform skin cells into basal cell carcinoma.
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An article in Oncogene further explains how ultraviolet (UV) radiation helps transform skin cells into basal cell carcinoma. Cells exposed to UV radiation ramp up production of protein kinase D, an enzyme that helps cells survive. The effect is cumulative: more exposure causes more protein kinase D expression, increasing the likelihood that DNA damaged skin cells survive and replicate. Pretreating skin cells with antioxidants reduced protein kinase D activation, suggesting that free radicals also contribute to skin cancer development.
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