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Opinion|Videos|December 14, 2023

Efficacy and Safety of Rechallenge With BRAF/MEK Inhibitors in Patients With BRAF-Mutated Metastatic Melanoma

Author(s)Michael Postow, MD, John M. Kirkwood, MD, Meredith McKean, MD, MPH

Panelists discuss the potential benefits of rechallenging patients with BRAF-mutated metastatic melanoma with BRAF/MEK inhibitors after a break from treatment, especially for those who initially responded well, and emphasizing the success of this approach in some cases, while highlighting the importance of monitoring and utilizing ctDNA tracking for more informed decision-making.

Episodes in this series

EP. 1 The Role of Biomarker Testing in the Management of Metastatic Melanoma

EP. 1 The Role of Biomarker Testing in the Management of Metastatic Melanoma

EP. 2 Best Practices for Biomarker Testing in Metastatic Melanoma

EP. 2 Best Practices for Biomarker Testing in Metastatic Melanoma

EP. 3 Differences Between Community and Academic Settings Regarding Biomarker Testing Practices in Metastatic Melanoma

EP. 3 Differences Between Community and Academic Settings Regarding Biomarker Testing Practices in Metastatic Melanoma

EP. 4 Treatment Options for Patients With Metastatic Melanoma With a BRAF Mutation

EP. 4 Treatment Options for Patients With Metastatic Melanoma With a BRAF Mutation

EP. 5 Factors Influencing Treatment Decision-Making In Patients With BRAF-Mutated Metastatic Melanoma

EP. 5 Factors Influencing Treatment Decision-Making In Patients With BRAF-Mutated Metastatic Melanoma

EP. 6 Frontline Treatment Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 6 Frontline Treatment Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 7 Common Adverse Effects Seen With BRAF/MEK Inhibitor Therapy in Patients With BRAF-Mutated Metastatic Melanoma

EP. 7 Common Adverse Effects Seen With BRAF/MEK Inhibitor Therapy in Patients With BRAF-Mutated Metastatic Melanoma

EP. 8 Choosing Between Available Combination BRAF/MEK Inhibitor Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 8 Choosing Between Available Combination BRAF/MEK Inhibitor Options for Patients With BRAF-Mutated Metastatic Melanoma

EP. 9 Encorafenib Plus Binimetinib for BRAF-Mutated Metastatic Melanoma: 7-Year Follow-Up Data From the COLUMBUS Trial

EP. 9 Encorafenib Plus Binimetinib for BRAF-Mutated Metastatic Melanoma: 7-Year Follow-Up Data From the COLUMBUS Trial

EP. 10 Efficacy and Safety of Rechallenge With BRAF/MEK Inhibitors in Patients With BRAF-Mutated Metastatic Melanoma

EP. 10 Efficacy and Safety of Rechallenge With BRAF/MEK Inhibitors in Patients With BRAF-Mutated Metastatic Melanoma

EP. 11 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Asymptomatic Brain Metastases

EP. 11 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Asymptomatic Brain Metastases

EP. 12 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Symptomatic Brain Metastases

EP. 12 Treatment Approaches For Patients With BRAF-Mutated Melanoma and Symptomatic Brain Metastases

EP. 13 Key Data on Combination Immunotherapies in BRAF-Mutated Melanoma with Brain Metastases

EP. 13 Key Data on Combination Immunotherapies in BRAF-Mutated Melanoma with Brain Metastases

EP. 14 The Future of Metastatic and Unresectable Melanoma Treatment

EP. 14 The Future of Metastatic and Unresectable Melanoma Treatment

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