
Opinion|Videos|December 21, 2023
Treatment Approaches For Patients With BRAF-Mutated Melanoma and Asymptomatic Brain Metastases
For patients with BRAF-mutated melanoma with asymptomatic brain metastases, immunotherapy, particularly the combination of ipilimumab and nivolumab, is the preferred treatment option due to its effectiveness and durability, as supported by the seven-year follow-up data from the CHECKMATE 204 trial.
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The NCCN update adds locally advanced CSCC to the category 2A listing cosibelimab received in metastatic disease in 2025.

The opinion supports 700 mg every 6 weeks after 12 weeks of 350 mg every 3 weeks; a European Commission decision is expected in the coming months.
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