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Opinion|Videos|July 24, 2024

Examining the Evolving 3L Treatment Landscape for mCRC

Author(s)John Marshall, MD, Al B. Benson III, MD, FACP, FACCC, FASCO , Kristen Ciombor, MD, MSCI

Colorectal cancer specialists examine treatment sequencing strategies for third-line and subsequent therapy settings, while also evaluating regorafenib's efficacy and real-world outcomes.

Episodes in this series

5 KOLs are featured in this panel.

EP. 1 Overview of Molecular Testing and Barriers in mCRC

5 KOLs are featured in this panel.

EP. 2 Clinical Considerations for 2L Treatment Sequencing in mCRC

5 KOLs are featured in this panel.

EP. 3 Novel Combination Regimens for 2L mCRC: Insights from ASCO 202

5 KOLs are featured in this panel.

EP. 4 Exploring Toxicities for Second Line Treatments in mCRC

5 KOLs are featured in this panel.

EP. 5 Existing Challenges for Patients Receiving 3L+ Therapies in mCRC

5 KOLs are featured in this panel.

EP. 6 Factors Driving 3L Therapeutic Selection for mCRC

5 KOLs are featured in this panel.

EP. 7 Exploring Data Outcomes From the SUNLIGHT Trial

5 KOLs are featured in this panel.

EP. 8 Fruquintinib for mCRC: Data from the FRESCO & FRESCO-2 Studies

5 KOLs are featured in this panel.

EP. 9 Examining the Evolving 3L Treatment Landscape for mCRC

5 KOLs are featured in this panel.

EP. 10 Additional Key Takeaways of ASCO 2024 Data in mCR

5 KOLs are featured in this panel.

EP. 11 Future Outlooks in the Treatment of Metastatic Colorectal Cancer

Briefly Given the latest approvals, is there a continued role for regorafenib in mCRC and how do real-world outcomes support its use? (Yisilamu P, et al. ASCO 2024. Abstract e15562)
Dr Marshall to Panel:Let’s explore sequencing strategies for CRC in the 3L setting and beyond. Discuss how new data and other considerations impact treatment selection and sequencing.
1. Dr Marshall to Panel: How would you describe your current approach to treatment sequencing?
2. Dr Benson: How do you approach treating patients with fruquintinib from FRESCO and FRESCO-2 studies according to prior treatment sequence? (Bekaii-Saab T, et al. ASCO 2024. Abstract 3579.)
  1. Impact of prior bevacizumab
3. Dr Fakih:Please comment on recently presented data from the SUNLIGHT study and the implications on your treatment sequencing:
  1. Impact of prior fluoropyrimidine (Fakih, et al. ASCO GI 2024. Abstract 114)
  2. Impact of prior bevacizumab
4. Dr Cohen: Regorafenib and/or TAS-102 sequencing (Signorelli C, et al. ASCO 2024. Abstract e15553)

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